Endocrine Abstracts

The endocrine disruptor compounds (EDC) (e.g. chlorobenzenes (ClB), phenurone (PU), monurone (MU), diurone (DU)) are accumulative, lipophilic, chemical pollutants that can disturb the homeostatic balance and exert tumorigenic effects. The aim of the present study was to investigate the effects of EDCs on the adrenocorticotropic hormone (ACTH) and prolactin (Prl) release in primary cell cultures derived from rat normal adenohypophysis and prolactinoma.The...

During the evaluation of hypercortisolism, distinction between Cushing’s disease (CD) and ectopic ACTH syndrome (EAS) may be problematic. Detailed medical history, diagnostic procedures and pitfalls associated with EAS of four cases are presented. All the four patients had ectopic Cushing’s syndrome due to typical bronchial carcinoids. Their mean age was 39 years, and the mean time from the presentation of Cushing’s symptomes until diagnosis and definitive cure ...